Somatic structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma

Neuroblastoma is a malignancy of the developing sympathetic nervous system that accounts for 12% of childhood cancer deaths. Like many childhood cancers, neuroblastoma shows a relative paucity of somatic single-nucleotide variants (SNVs) and small insertions and deletions (indels) compared to adult...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopez, Gonzalo, Conkrite, Karina L., Doepner, Miriam, Rathi, Komal S., Modi, Apexa, Vaksman, Zalman, Farra, Lance M., Hyson, Eric, Noureddine, Moataz, Wei, Jun S., Smith, Malcolm A., Asgharzadeh, Shahab, Seeger, Robert C., Khan, Javed, Auvil, Jaime Guidry, Gerhard, Daniela S., Maris, John M., Diskin, Sharon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545140/
https://www.ncbi.nlm.nih.gov/pubmed/32796005
http://dx.doi.org/10.1101/gr.252106.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545140/
https://www.ncbi.nlm.nih.gov/pubmed/32796005
http://dx.doi.org/10.1101/gr.252106.119

Ejemplares similares