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Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms

Eukaryotic genes often generate a variety of RNA isoforms that can lead to functionally distinct protein variants. The synthesis and stability of RNA isoforms is poorly characterized because current methods to quantify RNA metabolism use short-read sequencing and cannot detect RNA isoforms. Here we...

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Detalles Bibliográficos
Autores principales: Maier, Kerstin C., Gressel, Saskia, Cramer, Patrick, Schwalb, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545145/
https://www.ncbi.nlm.nih.gov/pubmed/32887688
http://dx.doi.org/10.1101/gr.257857.119