Steered molecular dynamic simulations reveal Marfan syndrome mutations disrupt fibrillin-1 cbEGF domain mechanosensitive calcium binding

Marfan syndrome (MFS) is a highly variable genetic connective tissue disorder caused by mutations in the calcium binding extracellular matrix glycoprotein fibrillin-1. Patients with the most severe form of MFS (neonatal MFS; nMFS) tend to have mutations that cluster in an internal region of fibrilli...

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Detalles Bibliográficos
Autores principales: Haller, Stephen J., Roitberg, Adrian E., Dudley, Andrew T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545174/
https://www.ncbi.nlm.nih.gov/pubmed/33033378
http://dx.doi.org/10.1038/s41598-020-73969-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545174/
https://www.ncbi.nlm.nih.gov/pubmed/33033378
http://dx.doi.org/10.1038/s41598-020-73969-2

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