Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors

Manganese (Mn) overexposure produces long-term cognitive deficits and reduces brain-derived neurotrophic factor (BDNF) in the hippocampus. However, it remains elusive whether Mn-dependent enhanced alpha-synuclein (α-Syn) expression, suggesting a multifaceted mode of neuronal toxicities, accounts for...

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Detalles Bibliográficos
Autores principales: Ma, Zhuo, Liu, Kuan, Li, Xin-Ru, Wang, Can, Liu, Chang, Yan, Dong-Ying, Deng, Yu, Liu, Wei, Xu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545185/
https://www.ncbi.nlm.nih.gov/pubmed/33033239
http://dx.doi.org/10.1038/s41419-020-03051-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545185/
https://www.ncbi.nlm.nih.gov/pubmed/33033239
http://dx.doi.org/10.1038/s41419-020-03051-2

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