Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies

The inducible co-stimulator (ICOS) is a member of the CD28/B7 superfamily, and delivers a positive co-stimulatory signal to activated T cells upon binding to its ligand (ICOS-L). Dysregulation of this pathway has been implicated in autoimmune diseases and cancer, and is currently under clinical inve...

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Detalles Bibliográficos
Autores principales: Rujas, Edurne, Cui, Hong, Sicard, Taylor, Semesi, Anthony, Julien, Jean-Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545189/
https://www.ncbi.nlm.nih.gov/pubmed/33033255
http://dx.doi.org/10.1038/s41467-020-18828-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545189/
https://www.ncbi.nlm.nih.gov/pubmed/33033255
http://dx.doi.org/10.1038/s41467-020-18828-4

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