The small molecule PSSM0332 disassociates the CRL4A(DCAF8) E3 ligase complex to decrease the ubiquitination of NcoR1 and inhibit the inflammatory response in a mouse sepsis-induced myocardial dysfunction model

Sepsis-induced myocardial dysfunction (SIMD) is a life-threatening complication caused by inflammation, but how it is initiated is still unclear. Several studies have shown that extracellular high mobility group box 1 (HMGB1), an important cytokine triggering inflammation, is overexpressed during th...

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Detalles Bibliográficos
Autores principales: Peng, Qingyun, Xu, Huifen, Xiao, Mingbing, Wang, Linhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545708/
https://www.ncbi.nlm.nih.gov/pubmed/33061810
http://dx.doi.org/10.7150/ijbs.50186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545708/
https://www.ncbi.nlm.nih.gov/pubmed/33061810
http://dx.doi.org/10.7150/ijbs.50186

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