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Successive Immunization With Epitope-Decreasing Dengue Antigens Induced Conservative Anti-Dengue Immune Responses

Repeated homologous antigen immunization has been hypothesized to hinder antibody diversification, whereas sequential immunization with heterologous immunogens can educate B cell differentiations towards conserved residues thereby facilitating the generation of cross-reactive immunity. In this study...

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Detalles Bibliográficos
Autores principales: Hou, Jue, Ye, Weijian, Loo, Hooi Linn, Wong, Lan Hiong, Chen, Jianzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545740/
https://www.ncbi.nlm.nih.gov/pubmed/33101316
http://dx.doi.org/10.3389/fimmu.2020.585133