The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

BACKGROUND: Protein kinase R (PKR) is implicated in the inflammatory response to bacterial infection while the role of PKR in sepsis-induced acute kidney injury (AKI) is largely unknown. This study aimed to investigate the effects of the specific PKR inhibitor C16 (C13H8N4OS) on lipopolysaccharide (...

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Detalles Bibliográficos
Autores principales: Zhou, Jialu, Zhang, Fan, Lin, Hongru, Quan, Minxue, Yang, Yaqin, Lv, Yanni, He, Zongnan, Qian, Yisong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Animal Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545781/
https://www.ncbi.nlm.nih.gov/pubmed/33017381
http://dx.doi.org/10.12659/MSM.926254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545781/
https://www.ncbi.nlm.nih.gov/pubmed/33017381
http://dx.doi.org/10.12659/MSM.926254

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