De novo missense variants disrupting protein–protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types

BACKGROUND: Whole-exome sequencing studies have been useful for identifying genes that, when mutated, affect risk for autism spectrum disorder (ASD). Nonetheless, the association signal primarily arises from de novo protein-truncating variants, as opposed to the more common missense variants. Despit...

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Detalles Bibliográficos
Autores principales: Chen, Siwei, Wang, Jiebiao, Cicek, Ercument, Roeder, Kathryn, Yu, Haiyuan, Devlin, Bernie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545940/
https://www.ncbi.nlm.nih.gov/pubmed/33032641
http://dx.doi.org/10.1186/s13229-020-00386-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545940/
https://www.ncbi.nlm.nih.gov/pubmed/33032641
http://dx.doi.org/10.1186/s13229-020-00386-7

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