The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson’s disease

Identifying disease-causing pathways and drugs that target them in Parkinson’s disease (PD) has remained challenging. We uncovered a PD-relevant pathway in which the stress-regulated heterodimeric transcription complex CHOP/ATF4 induces the neuron prodeath protein Trib3 that in turn depletes the neu...

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Detalles Bibliográficos
Autores principales: Aimé, Pascaline, Karuppagounder, Saravanan S., Rao, Apeksha, Chen, Yingxin, Burke, Robert E., Ratan, Rajiv R., Greene, Lloyd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545957/
https://www.ncbi.nlm.nih.gov/pubmed/31911115
http://dx.doi.org/10.1016/j.nbd.2019.104725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545957/
https://www.ncbi.nlm.nih.gov/pubmed/31911115
http://dx.doi.org/10.1016/j.nbd.2019.104725

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