Cargando…

Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice

Neuropsychological deficits, including impairments in learning and memory, occur after spinal cord injury (SCI). In experimental SCI models, we and others have reported that such changes reflect sustained microglia activation in the brain that is associated with progressive neurodegeneration. In the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yun, Ritzel, Rodney M., Khan, Niaz, Cao, Tuoxin, He, Junyun, Lei, Zhuofan, Matyas, Jessica J., Sabirzhanov, Boris, Liu, Simon, Li, Hui, Stoica, Bogdan A., Loane, David J., Faden, Alan I., Wu, Junfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545988/ https://www.ncbi.nlm.nih.gov/pubmed/33052221 http://dx.doi.org/10.7150/thno.49199

Ejemplares similares

Proton extrusion during oxidative burst in microglia exacerbates pathological acidosis following traumatic brain injury
por: Ritzel, Rodney M., et al.
Publicado: (2020)

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration
por: Ritzel, Rodney M., et al.
Publicado: (2023)

Dementia, Depression, and Associated Brain Inflammatory Mechanisms after Spinal Cord Injury
por: Li, Yun, et al.
Publicado: (2020)

Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain
por: Li, Yun, et al.
Publicado: (2023)

Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury
por: Ritzel, Rodney M., et al.
Publicado: (2019)

Age-related changes in plasma extracellular vesicles influence neuroinflammation in the brain and neurological outcome after traumatic spinal cord injury
por: Lei, Zhuofan, et al.
Publicado: (2023)

Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice
por: Ritzel, Rodney M., et al.
Publicado: (2022)

Inhibition of microRNA-711 limits angiopoietin-1 and Akt changes, tissue damage, and motor dysfunction after contusive spinal cord injury in mice
por: Sabirzhanov, Boris, et al.
Publicado: (2019)

Trehalose Enhances Long-term Recovery in 18-month-old Mice by Increasing Autophagy after Traumatic Brain Injury
por: Ritzel, Rodney, et al.
Publicado: (2021)

Trehalose Enhances Long-term Recovery in 18-month-old Mice by Increasing Autophagy after Traumatic Brain Injury
por: Ritzel, Rodney, et al.
Publicado: (2021)

Functions and Mechanisms of the Voltage-Gated Proton Channel Hv1 in Brain and Spinal Cord Injury
por: He, Junyun, et al.
Publicado: (2021)

Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice
por: Li, Yun, et al.
Publicado: (2022)

Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo
por: Wu, Junfang, et al.
Publicado: (2012)

Irradiation-Induced Upregulation of miR-711 Inhibits DNA Repair and Promotes Neurodegeneration Pathways
por: Sabirzhanov, Boris, et al.
Publicado: (2020)

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury
por: Kumar, Alok, et al.
Publicado: (2017)

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury
por: Byrnes, Kimberly R, et al.
Publicado: (2012)

The brain-bone marrow axis and its implications for chronic traumatic brain injury
por: Ritzel, Rodney M., et al.
Publicado: (2023)

Down-Regulation of miR-23a-3p Mediates Irradiation-Induced Neuronal Apoptosis
por: Sabirzhanov, Boris, et al.
Publicado: (2020)

Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain
por: Cao, Tuoxin, et al.
Publicado: (2020)

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction
por: Henry, Rebecca J., et al.
Publicado: (2023)

Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits
por: Hanscom, Marie, et al.
Publicado: (2021)

Delayed expression of cell cycle proteins contributes to astroglial scar formation and chronic inflammation after rat spinal cord contusion
por: Wu, Junfang, et al.
Publicado: (2012)

Don’t know what you got till it’s gone: microglial depletion and neurodegeneration
por: Graykowski, David, et al.
Publicado: (2021)

Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury
por: Aubrecht, Taryn G., et al.
Publicado: (2018)

Mithramycin selectively attenuates DNA-damage-induced neuronal cell death
por: Makarevich, Oleg, et al.
Publicado: (2020)

Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders
por: Han, Jinming, et al.
Publicado: (2018)

Targeting chronic and evolving neuroinflammation following traumatic brain injury to improve long-term outcomes: insights from microglial-depletion models
por: Henry, Rebecca J., et al.
Publicado: (2020)

Functional phenotyping of microglia highlights the dark relationship between chronic traumatic brain injury and normal age-related pathology
por: Ritzel, Rodney M., et al.
Publicado: (2022)

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury
por: Sarkar, Chinmoy, et al.
Publicado: (2015)

Microglial cell dysregulation in brain aging and neurodegeneration
por: von Bernhardi, Rommy, et al.
Publicado: (2015)

Microglial Potassium Channels: From Homeostasis to Neurodegeneration
por: Cocozza, Germana, et al.
Publicado: (2021)

Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading
por: Aires, Inês Dinis, et al.
Publicado: (2021)

Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma
por: Lipinski, Marta M., et al.
Publicado: (2015)

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
por: Hegdekar, Nivedita, et al.
Publicado: (2023)

Roles of microglial mitophagy in neurological disorders
por: Liu, Yang, et al.
Publicado: (2022)

Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration
por: Ernest James Phillips, Thomas, et al.
Publicado: (2021)

Brain innate immune response via miRNA-TLR7 sensing in polymicrobial sepsis
por: Zou, Lin, et al.
Publicado: (2022)

Cortical diurnal rhythms remain intact with microglial depletion
por: Barahona, Rocio A., et al.
Publicado: (2022)

NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury
por: Barrett, James P., et al.
Publicado: (2017)

Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease
por: Yan, Yi‐Qun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lfgkb6oeoc0hldd5u5k0hnshpb