Comparative Serum Analyses Identify Cytokines and Hormones Commonly Dysregulated as Well as Implicated in Promoting Osteolysis in MMP-2-Deficient Mice and Children

Deficiency of matrix metalloproteinase 2 (MMP-2) causes a complex syndrome characterized by multicentric osteolysis, nodulosis, and arthropathy (MONA) as well as cardiac valve defects, dwarfism and hirsutism. MMP-2 deficient (Mmp2(–/–)) mice are a model for this rare multisystem pediatric syndrome b...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarker, Hassan, Hardy, Eugenio, Haimour, Ayman, Karim, Mahmoud A., Scholl-Bürgi, Sabine, Martignetti, John A., Botto, Lorenzo D., Fernandez-Patron, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546215/
https://www.ncbi.nlm.nih.gov/pubmed/33101055
http://dx.doi.org/10.3389/fphys.2020.568718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546215/
https://www.ncbi.nlm.nih.gov/pubmed/33101055
http://dx.doi.org/10.3389/fphys.2020.568718

Ejemplares similares