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Energy Landscape for the Membrane Fusion Pathway in Influenza A Hemagglutinin From Discrete Path Sampling

The conformational change associated with membrane fusion for Influenza A Hemagglutinin is investigated with a model based upon pre- and post-fusion structures of the HA2 component. We employ computational methods based on the potential energy landscape framework to obtain an initial path connecting...

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Detalles Bibliográficos
Autores principales: Burke, David F., Mantell, Rosemary G., Pitt, Catherine E., Wales, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546250/
https://www.ncbi.nlm.nih.gov/pubmed/33102445
http://dx.doi.org/10.3389/fchem.2020.575195