The Signature Amino Acid Residue Serine 31 of HIV-1C Tat Potentiates an Activated Phenotype in Endothelial Cells

The natural cysteine to serine variation at position 31 of Tat in HIV-1C disrupts the dicysteine motif attenuating the chemokine function of Tat. We ask if there exists a trade-off in terms of a gain of function for HIV-1C Tat due to this natural variation. We constructed two Tat-expression vectors...

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Detalles Bibliográficos
Autores principales: Menon, Malini, Budhwar, Roli, Shukla, Rohit Nandan, Bankar, Kiran, Vasudevan, Madavan, Ranga, Udaykumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546421/
https://www.ncbi.nlm.nih.gov/pubmed/33101270
http://dx.doi.org/10.3389/fimmu.2020.529614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546421/
https://www.ncbi.nlm.nih.gov/pubmed/33101270
http://dx.doi.org/10.3389/fimmu.2020.529614

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