Thermostability of a recombinant G protein-coupled receptor expressed at high level in mammalian cell culture

Rational design of pharmaceutical drugs targeting integral membrane G protein-coupled receptors (GPCR) requires thorough understanding of ligand binding and mechanism of activation through high resolution structural studies of purified proteins. Due to inherent conformational flexibility of GPCR, st...

Descripción completa

Detalles Bibliográficos
Autores principales: Yeliseev, Alexei, van den Berg, Arjen, Zoubak, Lioudmila, Hines, Kirk, Stepnowski, Sam, Williston, Kyle, Yan, Wanhua, Gawrisch, Klaus, Zmuda, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546613/
https://www.ncbi.nlm.nih.gov/pubmed/33033368
http://dx.doi.org/10.1038/s41598-020-73813-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546613/
https://www.ncbi.nlm.nih.gov/pubmed/33033368
http://dx.doi.org/10.1038/s41598-020-73813-7

Ejemplares similares