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Thermostability of a recombinant G protein-coupled receptor expressed at high level in mammalian cell culture

Rational design of pharmaceutical drugs targeting integral membrane G protein-coupled receptors (GPCR) requires thorough understanding of ligand binding and mechanism of activation through high resolution structural studies of purified proteins. Due to inherent conformational flexibility of GPCR, st...

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Detalles Bibliográficos
Autores principales:	Yeliseev, Alexei, van den Berg, Arjen, Zoubak, Lioudmila, Hines, Kirk, Stepnowski, Sam, Williston, Kyle, Yan, Wanhua, Gawrisch, Klaus, Zmuda, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546613/ https://www.ncbi.nlm.nih.gov/pubmed/33033368 http://dx.doi.org/10.1038/s41598-020-73813-7

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