AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma

Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli signaling, but can develop mechanisms of Smoothened (SMO) inhibitor resistance. We previously identified a nuclear myocardin-r...

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Detalles Bibliográficos
Autores principales: Yao, Catherine D., Haensel, Daniel, Gaddam, Sadhana, Patel, Tiffany, Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., McKellar, Siegen, Shankar, Gautam, Aasi, Sumaira, Rieger, Kerri, Oro, Anthony E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546632/
https://www.ncbi.nlm.nih.gov/pubmed/33033234
http://dx.doi.org/10.1038/s41467-020-18762-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546632/
https://www.ncbi.nlm.nih.gov/pubmed/33033234
http://dx.doi.org/10.1038/s41467-020-18762-5

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