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AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma
Tumor heterogeneity and lack of knowledge about resistant cell states remain a barrier to targeted cancer therapies. Basal cell carcinomas (BCCs) depend on Hedgehog (Hh)/Gli signaling, but can develop mechanisms of Smoothened (SMO) inhibitor resistance. We previously identified a nuclear myocardin-r...
Autores principales: | Yao, Catherine D., Haensel, Daniel, Gaddam, Sadhana, Patel, Tiffany, Atwood, Scott X., Sarin, Kavita Y., Whitson, Ramon J., McKellar, Siegen, Shankar, Gautam, Aasi, Sumaira, Rieger, Kerri, Oro, Anthony E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546632/ https://www.ncbi.nlm.nih.gov/pubmed/33033234 http://dx.doi.org/10.1038/s41467-020-18762-5 |
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