Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

Toxic aggregated amyloid-β accumulation is a key pathogenic event in Alzheimer’s disease (AD), which derives from amyloid precursor protein (APP) through sequential cleavage by BACE1 (β-site APP cleavage enzyme 1) and γ-secretase. Small interfering RNAs (siRNAs) show great promise for AD therapy by...

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Detalles Bibliográficos
Autores principales: Zhou, Yutong, Zhu, Feiyan, Liu, Yang, Zheng, Meng, Wang, Yibin, Zhang, Dongya, Anraku, Yasutaka, Zou, Yan, Li, Jia, Wu, Haigang, Pang, Xiaobin, Tao, Wei, Shimoni, Olga, Bush, Ashley I., Xue, Xue, Shi, Bingyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546706/
https://www.ncbi.nlm.nih.gov/pubmed/33036977
http://dx.doi.org/10.1126/sciadv.abc7031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546706/
https://www.ncbi.nlm.nih.gov/pubmed/33036977
http://dx.doi.org/10.1126/sciadv.abc7031

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