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The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

Our ability to discover effective drug combinations is limited, in part by insufficient understanding of how the transcriptional response of two monotherapies results in that of their combination. We analyzed matched time course RNAseq profiling of cells treated with single drugs and their combinati...

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Detalles Bibliográficos
Autores principales: Diaz, Jennifer EL, Ahsen, Mehmet Eren, Schaffter, Thomas, Chen, Xintong, Realubit, Ronald B, Karan, Charles, Califano, Andrea, Losic, Bojan, Stolovitzky, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546737/
https://www.ncbi.nlm.nih.gov/pubmed/32945258
http://dx.doi.org/10.7554/eLife.52707