Exosomes secreted under hypoxia enhance stemness in Ewing’s sarcoma through miR-210 delivery

Intercellular communication between tumor cells within the hypoxic microenvironment promote aggressiveness and poor patient prognoses for reasons that remain unclear. Here we show that hypoxic Ewing’s sarcoma (EWS) cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS c...

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Detalles Bibliográficos
Autores principales: Kling, Matthew J., Chaturvedi, Nagendra K., Kesherwani, Varun, Coulter, Don W., McGuire, Timothy R., Sharp, J. Graham, Joshi, Shantaram S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546758/
https://www.ncbi.nlm.nih.gov/pubmed/33088424
http://dx.doi.org/10.18632/oncotarget.27702

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