Cargando…
Two Rationally Identified Novel Glitazones Reversed the Behavioral Dysfunctions and Exhibited Neuroprotection Through Ameliorating Brain Cytokines and Oxy-Radicals in ICV-LPS Neuroinflammatory Rat Model
The present study has planned to evaluate the neuroprotective activity of two novel glitazones in a neuroinflammatory rat model. Two novel glitazones were selected from an in-house virtual library of glitazones based on their docking scores against peroxisome proliferator-activated receptor-gamma (P...
Autores principales: | Justin, Antony, Ashwini, Premkumar, Jose, Jincy A., Jeyarani, Victoria, Dhanabal, S. P., Manisha, Chennu, Mandal, Subhankar P., Bhavimani, Guru, Prabitha, P., Yuvaraj, S., Prashantha Kumar, B. R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546828/ https://www.ncbi.nlm.nih.gov/pubmed/33100954 http://dx.doi.org/10.3389/fnins.2020.530148 |
Ejemplares similares
-
Novel glitazones as PPARγ agonists: molecular design, synthesis, glucose uptake activity and 3D QSAR studies
por: Mandal, Subhankar P., et al.
Publicado: (2018) -
Design and Development
of Novel Glitazones for Activation
of PGC-1α Signaling Via PPAR-γ Agonism: A Promising
Therapeutic Approach against Parkinson’s Disease
por: Prabhakaran, Prabitha, et al.
Publicado: (2023) -
Advances in PPARs Molecular Dynamics and Glitazones as a Repurposing Therapeutic Strategy through Mitochondrial Redox Dynamics against Neurodegeneration
por: Durai, Priya, et al.
Publicado: (2022) -
Are the adverse effects of glitazones linked to induced testosterone deficiency?
por: Carruthers, M, et al.
Publicado: (2008) -
Pleiotropic Effects of Glitazones: A Double Edge Sword?
por: Salomone, Salvatore
Publicado: (2011)