Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes

Aggregation of hyperphosphorylated TDP-43 is the hallmark pathological feature of the most common molecular form of frontotemporal lobar degeneration (FTLD–TDP) and in the vast majority of cases with amyotrophic lateral sclerosis (ALS–TDP). However, most of the specific phosphorylation sites remain...

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Detalles Bibliográficos
Autores principales: Neumann, Manuela, Frick, Petra, Paron, Francesca, Kosten, Jonas, Buratti, Emanuele, Mackenzie, Ian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547034/
https://www.ncbi.nlm.nih.gov/pubmed/32778941
http://dx.doi.org/10.1007/s00401-020-02207-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547034/
https://www.ncbi.nlm.nih.gov/pubmed/32778941
http://dx.doi.org/10.1007/s00401-020-02207-w

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