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The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV
The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion (680)SPRRAR↓SV(687) forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target cells. The insertion is absent in other CoV-s of...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547067/ https://www.ncbi.nlm.nih.gov/pubmed/33037310 http://dx.doi.org/10.1038/s41598-020-74101-0 |