Specific and direct modulation of the interaction between adhesion GPCR GPR56/ADGRG1 and tissue transglutaminase 2 using synthetic ligands

Blocking the interaction between cell-surface receptors and their ligands is a proven therapeutic strategy. Adhesion G protein-coupled receptors (aGPCRs) are key cell-surface receptors that regulate numerous pathophysiological processes, and their large extracellular regions (ECRs) mediate ligand bi...

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Detalles Bibliográficos
Autores principales: Salzman, Gabriel S., Zhang, Shu, Fernandez, Celia G., Araç, Demet, Koide, Shohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547085/
https://www.ncbi.nlm.nih.gov/pubmed/33037308
http://dx.doi.org/10.1038/s41598-020-74044-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547085/
https://www.ncbi.nlm.nih.gov/pubmed/33037308
http://dx.doi.org/10.1038/s41598-020-74044-6

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