Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus

DNA methylation is a crucial epigenetic mark for activity-dependent gene expression in neurons. Very little is known about how synaptic signals impact promoter methylation in neuronal nuclei. In this study we show that protein levels of the principal de novo DNA-methyltransferase in neurons, DNMT3A1...

Descripción completa

Detalles Bibliográficos
Autores principales: Bayraktar, Gonca, Yuanxiang, PingAn, Confettura, Alessandro D., Gomes, Guilherme M., Raza, Syed A., Stork, Oliver, Tajima, Shoji, Suetake, Isao, Karpova, Anna, Yildirim, Ferah, Kreutz, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547096/
https://www.ncbi.nlm.nih.gov/pubmed/32726795
http://dx.doi.org/10.1038/s41386-020-0780-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547096/
https://www.ncbi.nlm.nih.gov/pubmed/32726795
http://dx.doi.org/10.1038/s41386-020-0780-2

Ejemplares similares