Silica Nanoparticles Disturb Ion Channels and Transmembrane Potentials of Cardiomyocytes and Induce Lethal Arrhythmias in Mice

BACKGROUND: The toxicity of silica nanoparticles (SiNPs) on cardiac electrophysiology has seldom been evaluated. METHODS: Patch-clamp was used to investigate the acute effects of SiNP-100 (100 nm) and SiNP-20 (20 nm) on the transmembrane potentials (TMPs) and ion channels in cultured neonatal mouse...

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Detalles Bibliográficos
Autores principales: Liu, Ya-Qin, Xue, Si-Meng, Zhang, Peng, Xu, Lin-Na, Wang, De-Ping, Li, Guang, Cao, Ji-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547143/
https://www.ncbi.nlm.nih.gov/pubmed/33116478
http://dx.doi.org/10.2147/IJN.S261692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547143/
https://www.ncbi.nlm.nih.gov/pubmed/33116478
http://dx.doi.org/10.2147/IJN.S261692

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