Advancement in research and therapy of NF1 mutant malignant tumors

The NF1 gene encodes neurofibromin, which is one of the primary negative regulatory factors of the Ras protein. Neurofibromin stimulates the GTPase activity of Ras to convert it from an active GTP-bound form to its inactive GDP-bound form through its GTPase activating protein-related domain (GRD). T...

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Detalles Bibliográficos
Autores principales: Tao, Junyan, Sun, Dantong, Dong, Lina, Zhu, Hua, Hou, Helei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547409/
https://www.ncbi.nlm.nih.gov/pubmed/33061844
http://dx.doi.org/10.1186/s12935-020-01570-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547409/
https://www.ncbi.nlm.nih.gov/pubmed/33061844
http://dx.doi.org/10.1186/s12935-020-01570-8

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