Cargando…

The mechanisms of hydroxychloroquine in rheumatoid arthritis treatment: Inhibition of dendritic cell functions via Toll like receptor 9 signaling

Hydroxychloroquine (HCQ) is one of the most commonly prescribed immune-suppressants in treating rheumatoid arthritis (RA). Our previous research showed that HCQ suppressed RA development by inhibiting T follicular helper (Tfh) cells directly. Dendritic cells (DCs) serve as the link between innate an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Jiaochan, Li, Xing, Luo, Xiaoqing, He, Juan, Huang, Xuechan, Zhou, Qingyou, Han, Yanping, Jie, Hongyu, Zhuang, Jian, Li, Yehao, Yang, Fangyuan, Zhai, Zeqing, Wu, Shufan, He, Yi, Yang, Bin, Sun, Erwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. Published by Elsevier Masson SAS. 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547638/ https://www.ncbi.nlm.nih.gov/pubmed/33049581 http://dx.doi.org/10.1016/j.biopha.2020.110848

Ejemplares similares

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis
por: Zhai, Zeqing, et al.
Publicado: (2022)

Not only anti-inflammation, etanercept abrogates collagen-induced arthritis by inhibiting dendritic cell migration and maturation
por: Huang, Xuechan, et al.
Publicado: (2019)

Apigenin, a potent suppressor of dendritic cell maturation and migration, protects against collagen‐induced arthritis
por: Li, Xing, et al.
Publicado: (2015)

Blocking GSDME-mediated pyroptosis in renal tubular epithelial cells alleviates disease activity in lupus mice
por: Luo, Guihu, et al.
Publicado: (2022)

Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis
por: Zhuang, Lili, et al.
Publicado: (2022)

Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis
por: Jie, Hongyu, et al.
Publicado: (2016)

Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus
por: Yang, Fangyuan, et al.
Publicado: (2019)

Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation
por: Liao, Pan, et al.
Publicado: (2018)

Is hydroxychloroquine beneficial for COVID-19 patients?
por: Li, Xing, et al.
Publicado: (2020)

Protective effect of hydroxychloroquine on rheumatoid arthritis‐associated atherosclerosis
por: Shi, Na, et al.
Publicado: (2019)

Hydroxychloroquine and Cardiovascular Events in Patients with Rheumatoid Arthritis
por: Cordova Sanchez, Andres, et al.
Publicado: (2022)

Evaluating the Use of Hydroxychloroquine in Treating Patients With Rheumatoid Arthritis
por: Nazir, Armaan M, et al.
Publicado: (2021)

The Effect of Hydroxychloroquine on Cardiovascular Disease in Patients with Rheumatoid Arthritis
por: Mo, De-Gang, et al.
Publicado: (2022)

Hydroxychloroquine is neutral on incidental cataracts in patients with rheumatoid arthritis
por: Zhang, Zhibo, et al.
Publicado: (2023)

Novel Roles of Chloroquine and Hydroxychloroquine in Graves’ Orbitopathy Therapy by Targeting Orbital Fibroblasts
por: Guo, Yan, et al.
Publicado: (2020)

Evaluation of efficacy of combination of methotrexate and hydroxychloroquine with leflunomide in active rheumatoid arthritis
por: Shashikumar, N.S., et al.
Publicado: (2010)

Double Jeopardy Cardiomyopathy Requiring Heart Transplant: Hydroxychloroquine and Rheumatoid Arthritis
por: Muthukumar, Lakshmi, et al.
Publicado: (2020)

Retinal microvascular density analysis in patients with rheumatoid arthritis treated with hydroxychloroquine
por: Esser, Eliane Luisa, et al.
Publicado: (2022)

SAT-421 Novel Role of Chloroquine and Hydroxychloroquine in Graves’ Orbitopathy Therapy by Targeting Orbital Fibroblasts
por: Guo, Yan, et al.
Publicado: (2020)

Hydroxychloroquine use and progression or prognosis of COVID-19: a systematic review and meta-analysis
por: Zang, Yanxiang, et al.
Publicado: (2020)

Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, Toll-like receptors and rheumatoid synovial fluid
por: van Lieshout, Antoine WT, et al.
Publicado: (2006)

A Capillary Electrophoresis-Based Method for the Measurement of Hydroxychloroquine and Its Active Metabolite Desethyl Hydroxychloroquine in Whole Blood in Patients with Rheumatoid Arthritis
por: Sotgia, Salvatore, et al.
Publicado: (2022)

Hydroxychloroquine Attenuates Myocardial Ischemic and Post-Ischemic Reperfusion Injury by Inhibiting the Toll-Like Receptor 9 – Type I Interferon Pathway
por: Marsh, Katherine M, et al.
Publicado: (2022)

Hydroxychloroquine Use Is Associated With Decreased Incident Cardiovascular Events in Rheumatoid Arthritis Patients
por: Sharma, Tarun S., et al.
Publicado: (2016)

15-Hydroxyprostaglandin dehydrogenase is upregulated by hydroxychloroquine in rheumatoid arthritis fibroblast-like synoviocytes
por: KIM, HAK-JAE, et al.
Publicado: (2015)

The association between hydroxychloroquine treatment and cardiovascular morbidity among rheumatoid arthritis patients
por: Shapiro, Michael, et al.
Publicado: (2017)

Endomyocardial biopsy-proven hydroxychloroquine-induced cardiomyopathy in a patient with rheumatoid arthritis
por: Malhotra, Anureet, et al.
Publicado: (2023)

Hydroxychloroquine for treatment of rheumatoid arthritis: multifocal electroretinogram and laser flare-cell photometry study
por: Sebastiani, Stefano, et al.
Publicado: (2017)

Cutaneous Toll-like Receptor 9 Pre-Defines Hydroxychloroquine Dosage in Patients with Both Discoid and Subacute Lupus Erythematosus
por: Englert, Karolina A., et al.
Publicado: (2023)

Effect of Pingchuan Formula on Toll-Like Receptors and Dendritic Cells in an Asthmatic Mouse Model
por: Liu, Fei, et al.
Publicado: (2020)

Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis
por: Thwaites, Ryan, et al.
Publicado: (2014)

Toll‐like receptors matter: plasmacytoid dendritic cells in COVID‐19
por: Becker, Jennifer, et al.
Publicado: (2022)

Dendritic cell subsets in rheumatoid arthritis
por: Summers, K, et al.
Publicado: (2001)

Hydroxychloroquine Alleviates EAU by Inhibiting Uveitogenic T Cells and Ameliorating Retinal Vascular Endothelial Cells Dysfunction
por: Hu, Yunwei, et al.
Publicado: (2022)

Diagnosis and Treatment of Pythium Insidiosum Corneal Ulcer in a Chinese Child: A Case Report and Literature Review
por: He, Hong, et al.
Publicado: (2016)

Dendritic Cell Vaccines in Ovarian Cancer
por: Zhang, Xi, et al.
Publicado: (2021)

Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment
por: Wu, Di, et al.
Publicado: (2022)

Earliella scabrosa-associated postoperative Endophthalmitis after Phacoemulsification with intraocular lens implantation: a case report
por: He, Hong, et al.
Publicado: (2018)

Regulation of Atherosclerosis by Toll-Like Receptor 4 Induced by Serum Amyloid 1: A Systematic In Vitro Study
por: Chen, Jinhui, et al.
Publicado: (2022)

Characterization and Functional Analysis of Toll Receptor Genes during Antibacterial Immunity in the Green Peach Aphid Myzus persicae (Sulzer)
por: He, Li, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9k7gog76ah5cdsfgshbb0c1a7e