Molecular dynamics of the histamine H3 membrane receptor reveals different mechanisms of GPCR signal transduction

In this work, we studied the mechanisms of classical activation and inactivation of signal transduction by the histamine H3 receptor, a 7-helix transmembrane bundle G-Protein Coupled Receptor through long-time-scale atomistic molecular dynamics simulations of the receptor embedded in a hydrated doub...

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Detalles Bibliográficos
Autores principales: Herrera-Zúñiga, Leonardo David, Moreno-Vargas, Liliana Marisol, Ballaud, Luck, Correa-Basurto, José, Prada-Gracia, Diego, Pastré, David, Curmi, Patrick A., Arrang, Jean Michel, Maroun, Rachid C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547658/
https://www.ncbi.nlm.nih.gov/pubmed/33037273
http://dx.doi.org/10.1038/s41598-020-73483-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547658/
https://www.ncbi.nlm.nih.gov/pubmed/33037273
http://dx.doi.org/10.1038/s41598-020-73483-5

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