Characterization of a Cul9–Parkin double knockout mouse model for Parkinson’s disease

Mitochondrial quality control is essential for the long-term survival of postmitotic neurons. The E3 ubiquitin ligase Parkin promotes the degradation of damaged mitochondria via mitophagy and mutations in Parkin are a major cause of early-onset Parkinson’s disease (PD). Surprisingly however, mice de...

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Detalles Bibliográficos
Autores principales: Hollville, Emilie, Joers, Valerie, Nakamura, Ayumi, Swahari, Vijay, Tansey, Malú G., Moy, Sheryl S., Deshmukh, Mohanish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547682/
https://www.ncbi.nlm.nih.gov/pubmed/33037272
http://dx.doi.org/10.1038/s41598-020-73854-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547682/
https://www.ncbi.nlm.nih.gov/pubmed/33037272
http://dx.doi.org/10.1038/s41598-020-73854-y

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