A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands

Sialic acid-binding immunoglobulin-type lectins (Siglecs) are immunomodulatory receptors that are regulated by their glycan ligands. The connections between Siglecs and human disease motivate improved methods to detect Siglec ligands. Here, we describe a new versatile set of Siglec-Fc proteins for g...

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Detalles Bibliográficos
Autores principales: Rodrigues, Emily, Jung, Jaesoo, Park, Heajin, Loo, Caleb, Soukhtehzari, Sepideh, Kitova, Elena N., Mozaneh, Fahima, Daskhan, Gour, Schmidt, Edward N., Aghanya, Vivian, Sarkar, Susmita, Streith, Laura, St. Laurent, Chris D., Nguyen, Linh, Julien, Jean-Philippe, West, Lori J., Williams, Karla C., Klassen, John S., Macauley, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547722/
https://www.ncbi.nlm.nih.gov/pubmed/33037195
http://dx.doi.org/10.1038/s41467-020-18907-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547722/
https://www.ncbi.nlm.nih.gov/pubmed/33037195
http://dx.doi.org/10.1038/s41467-020-18907-6

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