TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition

Cancer stem cells (CSCs) have an established role in cancer progression and therapeutic resistance. The p63 proteins are important transcription factors which belong to the p53 family, but their function and mechanism in CSCs remain elusive. Here, we investigated the role of TAp63α in colorectal CSC...

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Detalles Bibliográficos
Autores principales: Chen, Yue, Wang, Meng-huan, Zhu, Jian-yun, Xie, Chun-feng, Li, Xiao-ting, Wu, Jie-shu, Geng, Shan-shan, Han, Hong-yu, Zhong, Cai-yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548006/
https://www.ncbi.nlm.nih.gov/pubmed/33040081
http://dx.doi.org/10.1038/s41389-020-00273-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548006/
https://www.ncbi.nlm.nih.gov/pubmed/33040081
http://dx.doi.org/10.1038/s41389-020-00273-z

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