USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638

Aberrant de novo lipogenesis (DNL) results in excessive hepatic lipid accumulation and liver steatosis, the causative factors of many liver diseases, such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma (HCC). However, the underlying m...

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Detalles Bibliográficos
Autores principales: Ni, Wenkai, Lin, Shengli, Bian, Saiyan, Zheng, Wenjie, Qu, Lishuai, Fan, Yihui, Lu, Cuihua, Xiao, Mingbing, Zhou, Pinghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548010/
https://www.ncbi.nlm.nih.gov/pubmed/33040080
http://dx.doi.org/10.1038/s41419-020-03075-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548010/
https://www.ncbi.nlm.nih.gov/pubmed/33040080
http://dx.doi.org/10.1038/s41419-020-03075-8

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