A Kinetic Analysis of DNA-Deoxy Guanine Adducts in the Nasal Epithelium Produced by Inhaled Formaldehyde in Rats—Assessing Contributions to Adduct Production From Both Endogenous and Exogenous Sources of Formaldehyde

Although formaldehyde is a normal constituent of tissues, lifetime inhalation exposures at 6 h/day, 5 days/week at concentrations ≥6 ppm caused a nonlinear increase in nasal tumors in rats with incidence reaching close to 50% at 15 ppm. Studies with heavy isotope labeled [(13)CD(2)]-formaldehyde per...

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Detalles Bibliográficos
Autores principales: Campbell Jr, Jerry L, Gentry, P Robinan, Clewell III, Harvey J, Andersen, Melvin E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Biotransformation, Toxicokinetics, And Pharmacokinetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548285/
https://www.ncbi.nlm.nih.gov/pubmed/32735340
http://dx.doi.org/10.1093/toxsci/kfaa122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548285/
https://www.ncbi.nlm.nih.gov/pubmed/32735340
http://dx.doi.org/10.1093/toxsci/kfaa122

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