Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice

Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent drug and its active metabolites have been poorly characterized to date. Blood and tissue levels were...

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Detalles Bibliográficos
Autores principales: Hu, Wen-juan, Chang, Lu, Yang, Ying, Wang, Xin, Xie, Yuan-chao, Shen, Jing-shan, Tan, Bo, Liu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548405/
https://www.ncbi.nlm.nih.gov/pubmed/33041326
http://dx.doi.org/10.1038/s41401-020-00537-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548405/
https://www.ncbi.nlm.nih.gov/pubmed/33041326
http://dx.doi.org/10.1038/s41401-020-00537-9

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