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Deuterium-Enabled Chiral Switching (DECS) Yields Chirally Pure Drugs from Chemically Interconverting Racemates
[Image: see text] Separation of the preferred enantiomer from racemic mixtures, i.e. “chiral switching,” often improves efficacy and reduces toxicity. However, this strategy is not applicable for all chiral compounds—particularly for molecules with hydrogen-containing chiral centers, which can be pr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549104/ https://www.ncbi.nlm.nih.gov/pubmed/33062153 http://dx.doi.org/10.1021/acsmedchemlett.0c00052 |