Inhibition of the Activity of Cyclophilin A Impedes Prolactin Receptor-Mediated Signaling, Mammary Tumorigenesis, and Metastases

Prolactin (PRL) and its receptor (PRLr) play important roles in the pathogenesis of breast cancer. Cyclophilin A (CypA) is a cis-trans peptidyl-prolyl isomerase (PPI) that is constitutively associated with the PRLr and facilitates the activation of the tyrosine kinase Jak2. Treatment with the non-im...

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Detalles Bibliográficos
Autores principales: Hakim, Shawn, Craig, Justin M., Koblinski, Jennifer E., Clevenger, Charles V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549119/
https://www.ncbi.nlm.nih.gov/pubmed/33083747
http://dx.doi.org/10.1016/j.isci.2020.101581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549119/
https://www.ncbi.nlm.nih.gov/pubmed/33083747
http://dx.doi.org/10.1016/j.isci.2020.101581

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