A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPR

The mitochondrial unfolded protein response (UPR(mt)) is a stress-activated pathway promoting mitochondrial recovery and defense against infection. In C. elegans, the UPR(mt) is activated during infection with the pathogen Pseudomonas aeruginosa—but only transiently. As this may reflect a pathogenic...

Descripción completa

Detalles Bibliográficos
Autores principales: Mahmud, Siraje Arif, Qureshi, Mohammed Adnan, Sapkota, Madhab, Pellegrino, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549759/
https://www.ncbi.nlm.nih.gov/pubmed/32997715
http://dx.doi.org/10.1371/journal.ppat.1008918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549759/
https://www.ncbi.nlm.nih.gov/pubmed/32997715
http://dx.doi.org/10.1371/journal.ppat.1008918

Ejemplares similares