Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate

The virions of enteroviruses such as poliovirus undergo a global conformational change after binding to the cellular receptor, characterized by a 4% expansion, and by the opening of holes at the two and quasi-three-fold symmetry axes of the capsid. The resultant particle is called a 135S particle or...

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Detalles Bibliográficos
Autores principales: Shah, Pranav N. M., Filman, David J., Karunatilaka, Krishanthi S., Hesketh, Emma L., Groppelli, Elisabetta, Strauss, Mike, Hogle, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549760/
https://www.ncbi.nlm.nih.gov/pubmed/32997730
http://dx.doi.org/10.1371/journal.ppat.1008920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549760/
https://www.ncbi.nlm.nih.gov/pubmed/32997730
http://dx.doi.org/10.1371/journal.ppat.1008920

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