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Quantifying the probability of pharmacological success to inform compound progression decisions

The Probability of Pharmacology Success, or PoPS, is a powerful metric to inform progression decisions by quantifying a compound’s overall pharmacological strength based on its mechanism. It is defined as the probability that X level of pharmacology is achieved in Y proportion of patients at a safe...

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Detalles Bibliográficos
Autores principales: Zhou, Xuan, Graff, Ole, Chen, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549803/
https://www.ncbi.nlm.nih.gov/pubmed/33045007
http://dx.doi.org/10.1371/journal.pone.0240234