A greedy classifier optimization strategy to assess ion channel blocking activity and pro-arrhythmia in hiPSC-cardiomyocytes

Novel studies conducting cardiac safety assessment using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are promising but might be limited by their specificity and predictivity. It is often challenging to correctly classify ion channel blockers or to sufficiently predict the...

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Detalles Bibliográficos
Autores principales: Raphel, Fabien, De Korte, Tessa, Lombardi, Damiano, Braam, Stefan, Gerbeau, Jean-Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549820/
https://www.ncbi.nlm.nih.gov/pubmed/32976482
http://dx.doi.org/10.1371/journal.pcbi.1008203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549820/
https://www.ncbi.nlm.nih.gov/pubmed/32976482
http://dx.doi.org/10.1371/journal.pcbi.1008203

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