Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis

BACKGROUND: Launching polytherapy with two or three antiseizure drugs (ASDs) in patients with epilepsy is still problematic. The choice of ASDs to combine them together is usually based on clinicians’ experience and it requires knowledge about mechanisms of action of the studied ASDs and their drug–...

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Detalles Bibliográficos
Autores principales: Łuszczki, Jarogniew J., Kondrat-Wróbel, Maria, Zagaja, Mirosław, Karwan, Sławomir, Bojar, Hubert, Plewa, Zbigniew, Florek-Łuszczki, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550287/
https://www.ncbi.nlm.nih.gov/pubmed/32507997
http://dx.doi.org/10.1007/s43440-020-00117-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550287/
https://www.ncbi.nlm.nih.gov/pubmed/32507997
http://dx.doi.org/10.1007/s43440-020-00117-y

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