Population pharmacokinetic approach for evaluation of treosulfan and its active monoepoxide disposition in plasma and brain on the basis of a rat model

PURPOSE: Efficacy of treosulfan, used in the treatment of marrow disorders, depends on the activity of its monoepoxy—(EBDM) and diepoxy compounds. The study aimed to describe the pharmacokinetics of treosulfan and EBDM in the rat plasma and brain by means of mixed-effects modelling. METHODS: The stu...

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Detalles Bibliográficos
Autores principales: Danielak, Dorota, Romański, Michał, Kasprzyk, Anna, Teżyk, Artur, Główka, Franciszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550288/
https://www.ncbi.nlm.nih.gov/pubmed/32474888
http://dx.doi.org/10.1007/s43440-020-00115-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550288/
https://www.ncbi.nlm.nih.gov/pubmed/32474888
http://dx.doi.org/10.1007/s43440-020-00115-0

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