Replacement of TCR Dβ With Immunoglobulin D(H) DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development

Enrichment for tyrosine in immunoglobulin CDR-H3 is due in large part to natural selection of germline immunoglobulin D(H) sequence. We have previously shown that when D(H) sequence is modified to reduce the contribution of tyrosine codons, epitope recognition is altered and B cell development, anti...

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Detalles Bibliográficos
Autores principales: Levinson, Michael, Khass, Mohamed, Burrows, Peter D., Schroeder, Harry W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550431/
https://www.ncbi.nlm.nih.gov/pubmed/33133088
http://dx.doi.org/10.3389/fimmu.2020.573413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550431/
https://www.ncbi.nlm.nih.gov/pubmed/33133088
http://dx.doi.org/10.3389/fimmu.2020.573413

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