NOTCH1 gene amplification promotes expansion of Cancer Associated Fibroblast populations in human skin

Cancer associated fibroblasts (CAFs) are a key component of the tumor microenvironment. Genomic alterations in these cells remain a point of contention. We report that CAFs from skin squamous cell carcinomas (SCCs) display chromosomal alterations, with heterogeneous NOTCH1 gene amplification and ove...

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Detalles Bibliográficos
Autores principales: Katarkar, Atul, Bottoni, Giulia, Clocchiatti, Andrea, Goruppi, Sandro, Bordignon, Pino, Lazzaroni, Francesca, Gregnanin, Ilaria, Ostano, Paola, Neel, Victor, Dotto, G. Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550609/
https://www.ncbi.nlm.nih.gov/pubmed/33046701
http://dx.doi.org/10.1038/s41467-020-18919-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550609/
https://www.ncbi.nlm.nih.gov/pubmed/33046701
http://dx.doi.org/10.1038/s41467-020-18919-2

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