Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A(2A) receptor

Biased agonism, the ability of agonists to differentially activate downstream signaling pathways by stabilizing specific receptor conformations, is a key issue for G protein-coupled receptor (GPCR) signaling. The C-terminal domain might influence this functional selectivity of GPCRs as it engages G...

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Detalles Bibliográficos
Autores principales: Navarro, Gemma, Gonzalez, Angel, Campanacci, Stefano, Rivas-Santisteban, Rafael, Reyes-Resina, Irene, Casajuana-Martin, Nil, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550916/
https://www.ncbi.nlm.nih.gov/pubmed/33101610
http://dx.doi.org/10.1016/j.csbj.2020.09.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550916/
https://www.ncbi.nlm.nih.gov/pubmed/33101610
http://dx.doi.org/10.1016/j.csbj.2020.09.028

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