Casein kinase 1α inhibits p53 downstream of MDM2-mediated autophagy and apoptosis in acute myeloid leukemia

Enhancement of autophagy serves as a promising therapeutic strategy for cancer, including acute myeloid leukemia (AML). Casein kinase 1α (CK1α), encoded by CSNK1A1, regulates Wnt/β-catenin, p53 and other key signaling pathways, and is critically involved in tumor progression. However, the relationsh...

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Detalles Bibliográficos
Autores principales: Xu, Wanling, Huang, Ziyang, Gan, Yifeng, Chen, Rongrong, Huang, Yisha, Xue, Bin, Jiang, Songfu, Yu, Zhijie, Yu, Kang, Zhang, Shenghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550986/
https://www.ncbi.nlm.nih.gov/pubmed/32901886
http://dx.doi.org/10.3892/or.2020.7760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550986/
https://www.ncbi.nlm.nih.gov/pubmed/32901886
http://dx.doi.org/10.3892/or.2020.7760

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