Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors

The process of viral integration into the host genome is an essential step of the HIV-1 life cycle. The viral integrase (IN) enzyme catalyzes integration. IN is an ideal therapeutic enzyme targeted by several drugs; raltegravir (RAL), elvitegravir (EVG), dolutegravir (DTG), and bictegravir (BIC) hav...

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Detalles Bibliográficos
Autores principales: Isaacs, Darren, Mikasi, Sello Given, Obasa, Adetayo Emmanuel, Ikomey, George Mondinde, Shityakov, Sergey, Cloete, Ruben, Jacobs, Graeme Brendon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552036/
https://www.ncbi.nlm.nih.gov/pubmed/32858802
http://dx.doi.org/10.3390/v12090936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552036/
https://www.ncbi.nlm.nih.gov/pubmed/32858802
http://dx.doi.org/10.3390/v12090936

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