Kaposi’s Sarcoma-Associated Herpesvirus Reactivation by Targeting of a dCas9-Based Transcription Activator to the ORF50 Promoter

CRISPR activation (CRISPRa) has revealed great potential as a tool to modulate the expression of targeted cellular genes. Here, we successfully applied the CRISPRa system to trigger the Kaposi’s sarcoma-associated herpesvirus (KSHV) reactivation in latently infected cells by selectively activating O...

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Detalles Bibliográficos
Autores principales: Elbasani, Endrit, Falasco, Francesca, Gramolelli, Silvia, Nurminen, Veijo, Günther, Thomas, Weltner, Jere, Balboa, Diego, Grundhoff, Adam, Otonkoski, Timo, Ojala, Päivi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552072/
https://www.ncbi.nlm.nih.gov/pubmed/32867368
http://dx.doi.org/10.3390/v12090952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552072/
https://www.ncbi.nlm.nih.gov/pubmed/32867368
http://dx.doi.org/10.3390/v12090952

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